Chronic social isolation reduces 5-HT neuronal activity via upregulated SK3 calcium-activated potassium channels

@inproceedings{Sargin2016ChronicSI,
  title={Chronic social isolation reduces 5-HT neuronal activity via upregulated SK3 calcium-activated potassium channels},
  author={Derya Sargin and David K Oliver and Evelyn K Lambe},
  booktitle={eLife},
  year={2016}
}
The activity of serotonin (5-HT) neurons is critical for mood regulation. In a mouse model of chronic social isolation, a known risk factor for depressive illness, we show that 5-HT neurons in the dorsal raphe nucleus are less responsive to stimulation. Probing the responsible cellular mechanisms pinpoints a disturbance in the expression and function of small-conductance Ca2+-activated K+ (SK) channels and reveals an important role for both SK2 and SK3 channels in normal regulation of 5-HT… CONTINUE READING
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