Chronic sleep fragmentation induces endothelial dysfunction and structural vascular changes in mice.

@article{Carreras2014ChronicSF,
  title={Chronic sleep fragmentation induces endothelial dysfunction and structural vascular changes in mice.},
  author={Alba Carreras and Shelley X. L. Zhang and Eduard Peris and Zhuanhong Qiao and Alex Gileles-Hillel and Richard Changxun Li and Yang Wang and David Gozal},
  journal={Sleep},
  year={2014},
  volume={37 11},
  pages={1817-24}
}
STUDY OBJECTIVES Sleep fragmentation (SF) is a common occurrence and constitutes a major characteristic of obstructive sleep apnea (OSA). SF has been implicated in multiple OSA-related morbidities, but it is unclear whether SF underlies any of the cardiovascular morbidities of OSA. We hypothesized that long-term SF exposures may lead to endothelial dysfunction and altered vessel wall structure. METHODS AND RESULTS Adult male C57BL/6J mice were fed normal chow and exposed to daylight SF or… CONTINUE READING
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