Chronic shear induces caveolae formation and alters ERK and Akt responses in endothelial cells.

@article{Boyd2003ChronicSI,
  title={Chronic shear induces caveolae formation and alters ERK and Akt responses in endothelial cells.},
  author={Nolan L. Boyd and Heonyong Park and Hong Yi and Yong Chool Boo and George P. Sorescu and Michelle Sykes and Hanjoong Jo},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2003},
  volume={285 3},
  pages={H1113-22}
}
Caveolae are plasmalemmal domains enriched with cholesterol, caveolins, and signaling molecules. Endothelial cells in vivo are continuously exposed to shear conditions, and their caveolae density and location may be different from that of static cultured cells. Here, we show that chronic shear exposure regulates formation and localization of caveolae and caveolin-1 in bovine aortic endothelial cells (BAEC). Chronic exposure (1 or 3 days) of BAEC to laminar shear increased the total number of… CONTINUE READING
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Caveolin cycles between plasma membrane caveolae and the H1121 CAVEOLAE FORMATION AND CELL SIGNALING CHANGES AJP-Heart Circ Physiol

  • PA Conrad, EJ Smart, YS Ying, RG Anderson, GS. Bloom
  • J Cell Biol
  • 2003
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