Chronic selective serotonin reuptake inhibition modulates endothelial dysfunction and oxidative state in rat chronic mild stress model of depression.

@article{Matchkov2015ChronicSS,
  title={Chronic selective serotonin reuptake inhibition modulates endothelial dysfunction and oxidative state in rat chronic mild stress model of depression.},
  author={Vladimir V Matchkov and Violetta V Kravtsova and Ove Wiborg and Christian Aalkjaer and Elena V Bouzinova},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2015},
  volume={309 8},
  pages={R814-23}
}
Major depression is known to be associated with cardiovascular abnormalities, and oxidative stress has been suggested to play a role. We tested the hypothesis that antidepressant treatment reduces oxidative stress and endothelial dysfunctions in the chronic mild stress (CMS) model of depression in rats. Rats with >30% reduction in sucrose intake after 4 wk of CMS were defined in the study as CMS-susceptible and compared with unstressed controls. Sixteen CMS-susceptible and eight unstressed rats… CONTINUE READING