Chronic rhinosinusitis with polyps and without polyps is associated with increased expression of suppressors of cytokine signaling 1 and 3.

@article{Park2013ChronicRW,
  title={Chronic rhinosinusitis with polyps and without polyps is associated with increased expression of suppressors of cytokine signaling 1 and 3.},
  author={Se Jin Park and Tae Hoon Kim and Young Joon Jun and Seung Hoon Lee and Hyei Yul Ryu and Kwang Jin Jung and Jong Yoon Jung and Gyu Ho Hwang and Sang Hag Lee},
  journal={The Journal of allergy and clinical immunology},
  year={2013},
  volume={131 3},
  pages={
          772-80
        }
}
BACKGROUND Chronic rhinosinusitis with nasal polyps (CRSwNP) or without nasal polyps (CRSsNP) is associated with expression of various cytokines. Suppressors of cytokine signaling (SOCS) regulate cytokine activity in a variety of cells, modulating inflammatory responses. OBJECTIVE We analyzed the expression and distribution pattern of SOCS1 and SOCS3 in CRSwNP and CRSsNP, and their cytokine-driven expression regulation in sinus mucosa. In addition, the expression levels of various cytokines… CONTINUE READING
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