Chronic rhinosinusitis and eosinophils: do macrolides have an effect?

@article{Wallwork2004ChronicRA,
  title={Chronic rhinosinusitis and eosinophils: do macrolides have an effect?},
  author={Ben D Wallwork and William B. Coman},
  journal={Current opinion in otolaryngology & head and neck surgery},
  year={2004},
  volume={12 1},
  pages={14-7}
}
PURPOSE OF REVIEW Long-term, low-dose macrolide therapy is effective in the treatment of chronic airway inflammation. It is believed that macrolide antibiotics produce this benefit through an antiinflammatory effect that is separate from their antibiotic effect. Eosinophils are key mediators in the inflammation seen in chronic rhinosinusitis. This review discusses the effect of macrolides on eosinophilic inflammation. RECENT FINDINGS In vitro studies recently have suggested that macrolides… CONTINUE READING