Chronic rhinosinusitis: from one disease to different phenotypes.

  title={Chronic rhinosinusitis: from one disease to different phenotypes.},
  author={C Bachert and Nan Zhang and Thibaut P J van Zele and P Gevaert},
  journal={Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology},
  volume={23 Suppl 22},
Chronic rhinosinusitis (CRS) has now been discovered as a frequent disease affecting about 11% of the European population. In clinical terms, CRS may be differentiated in two phenotypes, CRS with and without nasal polyps. This differentiation is also confirmed by immunohistochemical studies on the remodeling pattern of those diseases, identifying TGF-ß as… CONTINUE READING