Chronic restraint stress in adolescence differentially influences hypothalamic-pituitary-adrenal axis function and adult hippocampal neurogenesis in male and female rats.

@article{Barha2011ChronicRS,
  title={Chronic restraint stress in adolescence differentially influences hypothalamic-pituitary-adrenal axis function and adult hippocampal neurogenesis in male and female rats.},
  author={Cindy K. Barha and Susanne Brummelte and Stephanie E. Lieblich and Liisa A. M. Galea},
  journal={Hippocampus},
  year={2011},
  volume={21 11},
  pages={
          1216-27
        }
}
Previous studies have shown a relationship between adversity in adolescence and health outcomes in adulthood in a sex-specific manner. Adolescence is characterized by major changes in stress-responsive regions of the brain, including the hippocampus, the site of ongoing neurogenesis throughout the lifespan. Prepubertal male and female rats exhibit different acute reactions to chronic stress compared to adults, but less is known about whether these stress-induced changes persist into adulthood… CONTINUE READING
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