Chronic renal hypoxia after acute ischemic injury: effects of L-arginine on hypoxia and secondary damage.

@article{Basile2003ChronicRH,
  title={Chronic renal hypoxia after acute ischemic injury: effects of L-arginine on hypoxia and secondary damage.},
  author={D P Basile and Deborah L. Donohoe and Kelly Roethe and David L Mattson},
  journal={American journal of physiology. Renal physiology},
  year={2003},
  volume={284 2},
  pages={
          F338-48
        }
}
Ischemic acute renal failure (ARF) results in the permanent loss of peritubular capillaries and predisposes the progression of chronic renal failure. The present study was undertaken to determine whether renal hypoxia, which may represent an important mediator in disease progression, is persistently exacerbated after recovery from ARF. Rats were subjected to ischemia-reperfusion injury and allowed to recover for 5 or 20 wk. Immunohistochemistry of the hypoxia-sensitive marker 2-pimonidizole at… CONTINUE READING

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