Chronic rejection triggers the development of an aggressive intragraft immune response through recapitulation of lymphoid organogenesis.

@article{Thaunat2010ChronicRT,
  title={Chronic rejection triggers the development of an aggressive intragraft immune response through recapitulation of lymphoid organogenesis.},
  author={Olivier Thaunat and Natacha Patey and Giuseppina Caligiuri and Chantal Gautreau and Maria Mamani-Matsuda and Yahia Mekki and Marie-Caroline Dieu-Nosjean and G{\'e}rard Eberl and Ren{\'e} {\'E}cochard and Jean-Baptiste Michel and St{\'e}phanie Graff-Dubois and A Nicoletti},
  journal={Journal of immunology},
  year={2010},
  volume={185 1},
  pages={717-28}
}
The unwarranted persistence of the immunoinflammatory process turns this critical component of the body's natural defenses into a destructive mechanism, which is involved in a wide range of diseases, including chronic rejection. Performing a comprehensive analysis of human kidney grafts explanted because of terminal chronic rejection, we observed that the inflammatory infiltrate becomes organized into an ectopic lymphoid tissue, which harbors the maturation of a local humoral immune response… CONTINUE READING
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