Chronic psychotropic drug treatment causes differential expression of connexin 43 and GFAP in frontal cortex of rats

@article{Fatemi2008ChronicPD,
  title={Chronic psychotropic drug treatment causes differential expression of connexin 43 and GFAP in frontal cortex of rats},
  author={S Hossein Fatemi and Timothy D. Folsom and Teri J. Reutiman and Twinkle K. Pandian and Kari Bente Foss Haug},
  journal={Schizophrenia Research},
  year={2008},
  volume={104},
  pages={127-134}
}
Astrocytic markers glial fibrillary acidic protein (GFAP) and connexin 43 (CX43) are known to have altered expression in brains of subjects with psychiatric disorders including autism and major depression. The current study investigated whether GFAP and CX43 expressions are affected by several commonly used psychotropic medications (clozapine, fluoxetine, haloperidol, lithium, olanzapine, and valproic acid). Using SDS-PAGE and western blotting technique, we observed that CX43 protein expression… CONTINUE READING
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