Chronic protein kinase B (PKB/c-akt) activation leads to apoptosis induced by oxidative stress-mediated Foxo3a transcriptional up-regulation.

@article{Gorp2006ChronicPK,
  title={Chronic protein kinase B (PKB/c-akt) activation leads to apoptosis induced by oxidative stress-mediated Foxo3a transcriptional up-regulation.},
  author={Ankie G M van Gorp and Karen M. Pomeranz and Kim U. Birkenkamp and Rosaline C-Y Hui and Eric W-F Lam and Paul James Coffer},
  journal={Cancer research},
  year={2006},
  volume={66 22},
  pages={10760-9}
}
Increased protein kinase B (PKB; c-Akt) activation is a hallmark of diverse neoplasias providing both proliferative and antiapoptotic survival signals. In this study, we investigated the effect of chronic PKB activation on cellular survival and proliferation using cytokine-dependent bone marrow-derived Ba/F3 cells, in which PKBalpha activation can be directly, and specifically, induced by addition of 4-hydroxytamoxifen (4-OHT). Direct activation of PKB rescued Ba/F3 cells from cytokine… CONTINUE READING