Chronic progesterone treatment of male rats with unilateral 6-hydroxydopamine lesion of the dorsal striatum exasperates parkinsonian symptoms

@article{Chao2011ChronicPT,
  title={Chronic progesterone treatment of male rats with unilateral 6-hydroxydopamine lesion of the dorsal striatum exasperates parkinsonian symptoms},
  author={O. Chao and J. Huston and A. V. Bothmer and M. Pum},
  journal={Neuroscience},
  year={2011},
  volume={196},
  pages={228-236}
}
  • O. Chao, J. Huston, +1 author M. Pum
  • Published 2011
  • Psychology, Medicine
  • Neuroscience
  • Progesterone (PROG) shows neuroprotective effects in numerous lesion models, including a mouse model of Parkinson's disease (PD) induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). However, the possible beneficial effects of PROG on the behavioral and neurochemical impairments incurred in the hemiparkinsonian 6-hydroxydopamine (6-OHDA) model have not been investigated. Vehicle or PROG (4 mg/kg or 8 mg/kg) was daily applied over 13 days after unilateral injection of 6-OHDA into the… CONTINUE READING
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