Chronic production of angiotensin IV in the brain leads to hypertension that is reversible with an angiotensin II AT1 receptor antagonist.

Abstract

Angiotensin IV (Ang IV) is a metabolite of the potent vasoconstrictor angiotensin II (Ang II). Because specific binding sites for this peptide have been reported in numerous tissues including the brain, it has been suggested that a specific Ang IV receptor (AT4) might exist. Bolus injection of Ang IV in brain ventricles has been implicated in learning… (More)

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@article{Lochard2004ChronicPO, title={Chronic production of angiotensin IV in the brain leads to hypertension that is reversible with an angiotensin II AT1 receptor antagonist.}, author={Nadheige Lochard and Ga{\'e}tan Thibault and David W. Silversides and Rhian M Touyz and Timothy L. Reudelhuber}, journal={Circulation research}, year={2004}, volume={94 11}, pages={1451-7} }