Chronic prevention of μ-opioid receptor (MOR) G-protein coupling in the pontine parabrachial nucleus persistently decreases consumption of standard but not palatable food

@article{Ward2006ChronicPO,
  title={Chronic prevention of μ-opioid receptor (MOR) G-protein coupling in the pontine parabrachial nucleus persistently decreases consumption of standard but not palatable food},
  author={H. G. Ward and K. Simansky},
  journal={Psychopharmacology},
  year={2006},
  volume={187},
  pages={435-446}
}
  • H. G. Ward, K. Simansky
  • Published 2006
  • Medicine
  • Psychopharmacology
  • RationaleAcute pharmacological studies implicate μ-opioid receptors (MORs) in the parabrachial nucleus (PBN) of the brainstem in modulating eating. The long-term effects of preventing the cellular function of parabrachial MORs on food consumption remain to be elucidated.ObjectivesTo determine whether (1) chronic inhibition of MOR-mediated G-protein coupling in the PBN of rats would persistently reduce eating and (2) food properties dictate the effects of MOR blockade.Materials and methodsWe… CONTINUE READING
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