Chronic prenatal caffeine exposure impairs novel object recognition and radial arm maze behaviors in adult rats.

@article{Soellner2009ChronicPC,
  title={Chronic prenatal caffeine exposure impairs novel object recognition and radial arm maze behaviors in adult rats.},
  author={Deborah E Soellner and Theresa Grandys and Joseph L. Nu{\~n}ez},
  journal={Behavioural brain research},
  year={2009},
  volume={205 1},
  pages={191-9}
}
In this report, we demonstrate that chronic prenatal exposure to a moderate dose of caffeine disrupts novel object recognition and radial arm maze behaviors in adult male and female rats. Pregnant dams were administered either tap water or 75 mg/L caffeinated tap water throughout gestation. Oral self-administration in the drinking water led to an approximate maternal intake of 10mg/kg/day, equivalent to 2-3 cups of coffee/day in humans based on a metabolic body weight conversion. In adulthood… CONTINUE READING

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