Chronic potassium depletion induces renal injury, salt sensitivity, and hypertension in young rats.

@article{Ray2001ChronicPD,
  title={Chronic potassium depletion induces renal injury, salt sensitivity, and hypertension in young rats.},
  author={P. Ray and S. Suga and X. Liu and X. Huang and R. Johnson},
  journal={Kidney international},
  year={2001},
  volume={59 5},
  pages={
          1850-8
        }
}
BACKGROUND Chronic hypokalemia has been associated with renal hypertrophy, interstitial disease, and hypertension in both adult animals and humans. However, the effects of potassium (K(+)) depletion on the rapidly growing infant have not been well studied. The purpose of this study was to determine the effects of severe chronic dietary K(+) depletion on blood pressure (BP) and renal structural changes in young rats. METHODS Sprague-Dawley rats (50 +/- 5 g) were fed either a control or a… Expand
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References

SHOWING 1-10 OF 40 REFERENCES
Potassium depletion ameliorates hypertension in spontaneously hypertensive rats.
TLDR
K+ depletion has a potent antihypertensive effect in spontaneously hypertensive rats (SHR), and the administration of either K+-depleted diet prevented the development of hypertension and reversed established hypertension. Expand
Potassium protection against lesions of the renal tubules, arteries, and glomeruli and nephron loss in salt-loaded hypertensive Dahl S rats.
TLDR
Adding either KCl or K citrate to the 4% NaCl diet strikingly reduced the wall thickness to that found in the R rat, even though the BP was not reduced at all. Expand
Effect of salt deprivation on blood pressure in rats.
TLDR
In the normotensive Sprague-Dawley rat, low Na Cl intake elevated BP when compared with normal or high NaCl intake, and part of the increase in the uninephrectomized, Cl-supplemented group is not dependent on the renin-angiotensin system. Expand
Mechanism of hyperreninemia in the potassium-depleted rat.
  • S. Linas
  • Medicine, Chemistry
  • The Journal of clinical investigation
  • 1981
TLDR
PRA is increased in the KD isolated perfused kidney and this increase occurs independently of both the MD and of tissue K levels and is mediated by the renal vascular receptor. Expand
Morphometric analysis of kidney hypertrophy in rats after chronic potassium depletion.
TLDR
Overall kidney growth, epithelial volume of thick ascending limb (TAL) per tubule length was unchanged in IS and cortex and only slightly increased in outer stripe, which is consistent with previously reported increases in activity of enzymes involved in active reabsorption of K+ and Na+. Expand
Hypokalemic nephropathy in the rat. Role of ammonia in chronic tubular injury.
TLDR
Alkali supplementation reduced chronic tubulointerstitial disease in a rat model of hypokalemic nephropathy through ammonia-mediated activation of the alternative complement pathway. Expand
Atrial natriuretic peptide during the elevation in blood pressure induced by sodium restriction.
TLDR
Dietary sodium restriction can elevate blood pressure in the rat and that this response can be augmented by unilateral nephrectomy, and the exacerbation of the hypertension in sodium-restricted rats is not attributable to differences in PRA or plasma levels of iANP between one- and two-kidney, sodium- restricted rats. Expand
Renal vascular induction of TGF-β2 and renin by potassium depletion
TLDR
The results demonstrate that K + depletion induces TGF-β2 and renin in renal arterioles and in the JGA, and suggest that TGF -β2 may be an important mediator of JGA hypertrophy. Expand
Salt-sensitive hypertension develops after short-term exposure to Angiotensin II.
TLDR
A new model of salt-sensitive hypertension induced by transient exposure to pressor doses of Ang II, related to microvascular injury with peritubular capillary loss coupled with functional changes, such as a loss in intrarenal nitric oxide formation, that could alter the ability of the kidney to excrete a salt load is reported. Expand
Dietary sodium restriction and development of hypertension in spontaneously hypertensive rats.
TLDR
The results indicate that dietary sodium restriction can ameliorate the development of hypertension in SHR, but only when the sodium levels are so low as to affect overall growth. Expand
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3
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