Chronic peroxisome proliferator-activated receptor gamma (PPARgamma) activation of epididymally derived white adipocyte cultures reveals a population of thermogenically competent, UCP1-containing adipocytes molecularly distinct from classic brown adipocytes.

@article{Petrovic2010ChronicPP,
  title={Chronic peroxisome proliferator-activated receptor gamma (PPARgamma) activation of epididymally derived white adipocyte cultures reveals a population of thermogenically competent, UCP1-containing adipocytes molecularly distinct from classic brown adipocytes.},
  author={Natasa B Petrovic and Tomas B. Wald{\'e}n and Irina G Shabalina and James A. Timmons and Barbara A Cannon and Jan Nedergaard},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 10},
  pages={
          7153-64
        }
}
The recent insight that brown adipocytes and muscle cells share a common origin and in this respect are distinct from white adipocytes has spurred questions concerning the origin and molecular characteristics of the UCP1-expressing cells observed in classic white adipose tissue depots under certain physiological or pharmacological conditions. Examining precursors from the purest white adipose tissue depot (epididymal), we report here that chronic treatment with the peroxisome proliferator… CONTINUE READING
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