Chronic perifusion of rat islets with palmitate suppresses glucose-stimulated insulin release.

@article{Elks1993ChronicPO,
  title={Chronic perifusion of rat islets with palmitate suppresses glucose-stimulated insulin release.},
  author={Martin Elks},
  journal={Endocrinology},
  year={1993},
  volume={133 1},
  pages={208-14}
}
To test the hypothesis that the high circulating FFA levels in the diabetes of obesity could contribute to the altered dynamics of insulin secretion seen in that condition, insulin release was measured in isolated perifused rat islet cells, without or with added palmitate. Acutely, as in other systems, palmitate (1 mM) stimulated insulin release. Palmitate (1 mM) suppressed both first and second phase insulin release after 2, 3, or 4 h of perifusion, but not after 1 h. No significant effect was… CONTINUE READING

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