Chronic partial ureteral obstruction and the developing kidney

@article{Chevalier2007ChronicPU,
  title={Chronic partial ureteral obstruction and the developing kidney},
  author={Robert L. Chevalier},
  journal={Pediatric Radiology},
  year={2007},
  volume={38},
  pages={35-40}
}
Although congenital urinary tract obstruction is a common disorder, its pathophysiology remains poorly understood and clinical practice is controversial. Animal models have been used to elucidate the mechanisms responsible for obstructive nephropathy, and the models reveal that renal growth and function are impaired in proportion to the severity and duration of obstruction. Ureteral obstruction in the neonatal rat or mouse leads to activation of the renin-angiotensin system, renal infiltration… CONTINUE READING

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