Chronic pancreatitis

@article{Beyer2020ChronicP,
  title={Chronic pancreatitis},
  author={Georg Beyer and Aida Habtezion and J Werner and Markus M. Lerch and Julia Mayerle},
  journal={The Lancet},
  year={2020},
  volume={396},
  pages={499-512}
}
Chronic pancreatitis is a multifactorial, fibroinflammatory syndrome in which repetitive episodes of pancreatic inflammation lead to extensive fibrotic tissue replacement, resulting in chronic pain, exocrine and endocrine pancreatic insufficiency, reduced quality of life, and a shorter life expectancy. The incidence and prevalence of chronic pancreatitis is rising and no curative treatment is available. Using novel diagnostic algorithms, definitive chronic pancreatitis can be diagnosed by… 
32 Citations
[Chronic pancreatitis: update diagnostic and therapeutic concepts].
TLDR
The clinical management of complex patients with local complications requires an interdisciplinary approach to tailor available therapeutic modalities depending on the stage of the disease and pre-existing comorbidities.
Progression from acute to chronic pancreatitis
  • I. Roberts-Thomson
  • Medicine
    JGH open : an open access journal of gastroenterology and hepatology
  • 2021
TLDR
Patients with recurrent acute pancreatitis are more likely to have had severe or complicated disease during the index episode with prolonged elevation of serum amylase or lipase, and some of the idiopathic group have recurrent episodes of mild pancreatitis, usually with normal findings at ERCP.
Low and high pancreatic amylase is associated with pancreatic cancer and chronic pancreatitis
TLDR
In apparently healthy individuals from the general population, extreme low and extreme high plasma pancreatic amylase were associated with 2–threefold higher risk of both pancreatic cancer and chronic pancreatitis.
Factors associated with prior acute pancreatitis episodes among patients with chronic pancreatitis.
  • N. Ru, Jia-Hui Zhu, +10 authors Z. Liao
  • Medicine
    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
  • 2021
TLDR
SPINK1 mutations served as protective factor for AP episodes, suggesting SPINK1 mutation might play a pathogenic role in CP occurrence with occult clinical manifestations.
Prevalence of Myocardial Infarction in Patients With Chronic Pancreatitis
TLDR
It was showed that CP is associated with comorbidities, which can increase the prevalence and OR of MI, which was a strong predictor for MI in the CP group.
Starvation Ketoacidosis With Hypoglycemia in a Patient With Chronic Pancreatitis
TLDR
A case of starvation ketoacidosis in a 44-year-old Japanese man with chronic alcoholic pancreatitis is presented, and it is shown that starvation rarely causes hypoglycemia and severe keto acids, but they can be induced by short-term fasting in patients with decreased pancreatic function.
Pancreatic Cancer–Related Mutational Burden Is Not Increased in a Patient Cohort With Clinically Severe Chronic Pancreatitis
TLDR
Overall, it was showed that even in those patients with chronic pancreatitis severe enough to warrant total pancreatectomy with islet autotransplantation, pancreatic cancer–related mutational burden is not appreciably increased.
The Impacts of Genetic and Environmental Factors on the Progression of Chronic Pancreatitis.
  • N. Ru, Xiao-nan Xu, +8 authors Zhuan Liao
  • Medicine
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
  • 2021
TLDR
While rare pathogenic mutations in the four major susceptibility genes for CP were not significantly correlated with the development of pancreatic insufficiency, environmental factors (either alcohol consumption or smoking) significantly accelerated disease progression.
Surgery for chronic pancreatitis: the comparison of two high-volume centers reveals lack of a uniform operative management
TLDR
The comparison of the surgical attitude towards CP between two surgical centers in Italy and Austria proved that a consistent approach to this pathology still is lacking, and the identification of common guidelines and labels of surgical eligibility is advisable in order to avoid interinstitutional treatment disparities.
Molecular mechanisms of pancreatic myofibroblast activation in chronic pancreatitis and pancreatic ductal adenocarcinoma
TLDR
This review analyzes the key signaling events that drive PMF activation including, initiating signals from transforming growth factor-β1, platelet derived growth factor, as well as other microenvironmental cues, like hypoxia and extracellular matrix rigidity.
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References

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TLDR
This definition represents, in a nutshell, how chronic pancreatitis presents clinically, what the underlying mechanism is recurrent inflammation leading to fibrosis, the key clinical complications that can be expected and should be looked for, as well as the long-term prognosis of affected patients.
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TLDR
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TLDR
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TLDR
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TLDR
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    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
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TLDR
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TLDR
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TLDR
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