Chronic pain: the role of learning and brain plasticity.

  title={Chronic pain: the role of learning and brain plasticity.},
  author={Ali M. Reda Mansour and Melissa A. Farmer and Marwan N. Baliki and A Vania Apkarian},
  journal={Restorative neurology and neuroscience},
  volume={32 1},
Based on theoretical considerations and recent observations, we argue that continued suffering of chronic pain is critically dependent on the state of motivational and emotional mesolimbic-prefrontal circuitry of the brain. The plastic changes that occur within this circuitry in relation to nociceptive inputs dictate the transition to chronic pain, rendering the pain less somatic and more affective in nature. This theoretical construct is a strong departure from the traditional scientific view… CONTINUE READING
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