Chronic pain, chronic stress and depression: coincidence or consequence?

@article{BlackburnMunro2001ChronicPC,
  title={Chronic pain, chronic stress and depression: coincidence or consequence?},
  author={Gordon J Blackburn-Munro and Ruth E Blackburn-Munro},
  journal={Journal of neuroendocrinology},
  year={2001},
  volume={13 12},
  pages={1009-23}
}
Chronic pain and depressive illness are debilitating disease states that are variably resistant to currently available therapeutic agents. Animal models of chronic pain are associated with activation of the hypothalamo-pituitary-adrenal (HPA) axis, upon which chronic pain acts as an inescapable stressor. Inescapable stress is also associated with… CONTINUE READING