Chronic oxytocin administration inhibits food intake, increases energy expenditure, and produces weight loss in fructose-fed obese rhesus monkeys.

@article{Blevins2015ChronicOA,
  title={Chronic oxytocin administration inhibits food intake, increases energy expenditure, and produces weight loss in fructose-fed obese rhesus monkeys.},
  author={James E. Blevins and James Graham and Gregory J. Morton and Karen L. Bales and Michael J. Schwartz and Denis G. Baskin and P. Havel},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2015},
  volume={308 5},
  pages={R431-8}
}
Despite compelling evidence that oxytocin (OT) is effective in reducing body weight (BW) in diet-induced obese (DIO) rodents, studies of the effects of OT in humans and rhesus monkeys have primarily focused on noningestive behaviors. The goal of this study was to translate findings in DIO rodents to a preclinical translational model of DIO. We tested the hypothesis that increased OT signaling would reduce BW in DIO rhesus monkeys by inhibiting food intake and increasing energy expenditure (EE… CONTINUE READING
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