Chronic oxidative stress induces a tissue-specific reduction in telomere length in CAST/Ei mice.

@article{Cattan2008ChronicOS,
  title={Chronic oxidative stress induces a tissue-specific reduction in telomere length in CAST/Ei mice.},
  author={Val{\'e}rie Cattan and N. Mercier and Jeffrey P. Gardner and V{\'e}ronique R{\'e}gnault and Carlos Labat and Jenni Heidi Eveliina M{\"a}ki-Jouppila and Rosine Mayap Nzietchueng and Athanase B{\'e}n{\'e}tos and Masayuki Kimura and Abraham Aviv and Patrick Lacolley},
  journal={Free radical biology & medicine},
  year={2008},
  volume={44 8},
  pages={1592-8}
}
We examine whether increased oxidative stress in vivo promotes telomere shortening in CAST/Ei mice. We explored the effects of L-buthionine sulfoximine treatment (BSO) on telomere length. BSO shortened telomere length in white fat, brown fat, skin, tail, and testis in concert with diminished tissue glutathione content, increased tissue carbonyl content, and increased plasma advanced oxidized protein products. Telomerase activity was mainly detected in testis but no reduction of telomerase… CONTINUE READING

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