Chronic oxidative stress compromises telomere integrity and accelerates the onset of senescence in human endothelial cells.

@article{Kurz2004ChronicOS,
  title={Chronic oxidative stress compromises telomere integrity and accelerates the onset of senescence in human endothelial cells.},
  author={David J. Kurz and Stephanie Decary and Ying Hong and Elisabeth Trivier and Alexander Akhmedov and Jorge D. Erusalimsky},
  journal={Journal of cell science},
  year={2004},
  volume={117 Pt 11},
  pages={
          2417-26
        }
}
Replicative senescence and oxidative stress have been implicated in ageing, endothelial dysfunction and atherosclerosis. Replicative senescence is determined primarily by telomere integrity. In endothelial cells the glutathione redox-cycle plays a predominant role in the detoxification of peroxides. The aim of this study was to elucidate the role of the glutathione-dependent antioxidant system on the replicative capacity and telomere dynamics of cultured endothelial cells. Human umbilical vein… CONTINUE READING

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