Chronic overexpression of corticotropin-releasing factor from the central amygdala produces HPA axis hyperactivity and behavioral anxiety associated with gene-expression changes in the hippocampus and paraventricular nucleus of the hypothalamus.

Abstract

Environmental stress has been demonstrated to increase susceptibility for mood and anxiety disorders, and hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis, the primary endocrine response to stress, is often observed in these patients. HPA axis activation is initiated by corticotropin-releasing factor (CRF) from the hypothalamus, leading to the… (More)
DOI: 10.1016/j.psyneuen.2011.04.014

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@article{Flandreau2012ChronicOO, title={Chronic overexpression of corticotropin-releasing factor from the central amygdala produces HPA axis hyperactivity and behavioral anxiety associated with gene-expression changes in the hippocampus and paraventricular nucleus of the hypothalamus.}, author={Elizabeth I. Flandreau and Kerry J. Ressler and Michael J. Owens and Charles B. Nemeroff}, journal={Psychoneuroendocrinology}, year={2012}, volume={37 1}, pages={27-38} }