Chronic oral or intraarticular administration of docosahexaenoic acid reduces nociception and knee edema and improves functional outcomes in a mouse model of Complete Freund’s Adjuvant–induced knee arthritis

@inproceedings{TorresGuzman2014ChronicOO,
  title={Chronic oral or intraarticular administration of docosahexaenoic acid reduces nociception and knee edema and improves functional outcomes in a mouse model of Complete Freund’s Adjuvant–induced knee arthritis},
  author={Ana M Torres-Guzman and Carlos Eduardo Morado-Urbina and Perla Abigail Alvarado-V{\'a}zquez and Rosa Issel Acosta-Gonz{\'a}lez and Aracely Evangelina Ch{\'a}vez-Pi{\~n}a and Rosa Mariana Montiel-Ruiz and Juan Miguel Jim{\'e}nez-Andrade},
  booktitle={Arthritis research & therapy},
  year={2014}
}
INTRODUCTION Clinical and preclinical studies have shown that supplementation with ω-3 polyunsaturated fatty acids (ω-3 PUFAs) reduce joint destruction and inflammation present in rheumatoid arthritis (RA). However, the effects of individual ω-3 PUFAs on chronic arthritic pain have not been evaluated to date. Thus, our aim in this study was to examine whether purified docosahexaenoic acid (DHA, an ω-3 PUFA) reduces spontaneous pain-related behavior and knee edema and improves functional… CONTINUE READING
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