Chronic oral exposure to the aldehyde pollutant acrolein induces dilated cardiomyopathy.

@article{Ismahil2011ChronicOE,
  title={Chronic oral exposure to the aldehyde pollutant acrolein induces dilated cardiomyopathy.},
  author={Mohamed Ameen Ismahil and Tariq Parwaiz Hamid and Petra Haberzettl and Yan Gu and Bysani Chandrasekar and Sanjay Mohan Srivastava and Aruni Bhatnagar and Sumanth D. Prabhu},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2011},
  volume={301 5},
  pages={
          H2050-60
        }
}
Environmental triggers of dilated cardiomyopathy are poorly understood. Acute exposure to acrolein, a ubiquitous aldehyde pollutant, impairs cardiac function and cardioprotective responses in mice. Here, we tested the hypothesis that chronic oral exposure to acrolein induces inflammation and cardiomyopathy. C57BL/6 mice were gavage-fed acrolein (1 mg/kg) or water (vehicle) daily for 48 days. The dose was chosen based on estimates of human daily unsaturated aldehyde consumption. Compared with… CONTINUE READING
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