Chronic oral administration of 1-nitrosopiperazine at high doses to MRC rats

Abstract

1-Nitrosopiperazine was fed to two groups of rats as drinking water solutions containing 400 mg/liter (3.5 millimolar) and 800 mg/liter (7.0 milli-molar), respectively. The treatment was 20 ml per rat per day, 5 days per week for life. In both groups many animals died with olfactory tumors (mostly esthesioneuroblastomas), the first at 36 weeks in the higher… (More)
DOI: 10.1007/BF02571691

Topics

Cite this paper

@article{Love1977ChronicOA, title={Chronic oral administration of 1-nitrosopiperazine at high doses to MRC rats}, author={Lori A. Love and William Lijinsky and Larry K. Keefer and H. Garcia}, journal={Zeitschrift f{\"u}r Krebsforschung und Klinische Onkologie}, year={1977}, volume={89}, pages={69-73} }