Chronic opiate receptor activation in vivo alters the level of G-protein subunits in guinea-pig myenteric plexus.

@article{Lang1989ChronicOR,
  title={Chronic opiate receptor activation in vivo alters the level of G-protein subunits in guinea-pig myenteric plexus.},
  author={Judith C. Lang and R{\"u}diger Schulz},
  journal={Neuroscience},
  year={1989},
  volume={32 2},
  pages={503-10}
}
Studies with the longitudinal muscle-myenteric plexus preparation of the guinea-pig ileum were undertaken to investigate the relationship between guanine nucleotide-binding proteins (G-proteins) and chronic opioid receptor activation in vivo. Treatment with the narcotic agonist fentanyl, at doses which render the preparation tolerant and dependent, led to an increase of pertussis toxin-catalysed incorporation of ADP-ribose in a protein of approximately 40,000 mol. wt. Quantitative… CONTINUE READING