Chronic obstructive pulmonary disease and inhaled steroids alter surfactant protein D (SP-D) levels: a cross-sectional study

@article{Sims2008ChronicOP,
  title={Chronic obstructive pulmonary disease and inhaled steroids alter surfactant protein D (SP-D) levels: a cross-sectional study},
  author={Michael W Sims and Ruth Tal-Singer and Sonja Kierstein and Ali Imran Musani and Michael F. Beers and Reynold A Panettieri and Angela Haczku},
  journal={Respiratory Research},
  year={2008},
  volume={9},
  pages={13 - 13}
}
BACKGROUND Surfactant protein D (SP-D), an innate immune molecule, plays an important protective role during airway inflammation. Deficiency of this molecule induces emphysematous changes in murine lungs, but its significance in human COPD remains unclear. METHODS We collected bronchoalveolar lavage fluid from 20 subjects with varying degrees of COPD (8 former smokers and 12 current smokers) and 15 asymptomatic healthy control subjects (5 never smokers, 3 remote former smokers, and 7 current… CONTINUE READING
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