Chronic nitric oxide inhibition with l-NAME: effects on autonomic control of the cardiovascular system.

@article{Scrogin1998ChronicNO,
  title={Chronic nitric oxide inhibition with l-NAME: effects on autonomic control of the cardiovascular system.},
  author={Karie E. Scrogin and Daniel C. Hatton and Yue Chi and Friedrich C. Luft},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={1998},
  volume={274 2},
  pages={R367-R374}
}
To determine whether increased sympathetic activity contributes to the hypertension induced by chronic exposure to moderate nitric oxide synthase (NOS) inhibition, various indexes of autonomic function were measured in rats given the NOS inhibitor N G-nitro-l-arginine methyl ester (l-NAME, 10 mg/100 ml, ≅16 mg ⋅ kg-1 ⋅ day-1) in the drinking water. One week of treatment raised blood pressure (139 ± 3 vs. 106 ± 1 mmHg; P < 0.01) and lowered heart rate (319 ± 4 vs. 379 ± 6 beats/min, P < 0.01).l… CONTINUE READING
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