Chronic nitric oxide deprivation induces an adaptive antioxidant status in human endothelial cells.


In a previous work, we showed an increased cell motility due to the accumulation and transcriptional activation of the Hypoxia Inducible Factor-1α (HIF-1α) and a reduced mitochondrial energy production in an in vitro model of endothelial dysfunction (ED) represented by human endothelial cells (ECs) chronically deprived of nitric oxide (NO) by L-NAME… (More)
DOI: 10.1016/j.cellsig.2013.07.026