Chronic nifedipine dosing enhances cephalexin bioavailability and intestinal absorption in conscious rats.

@article{Berlioz2000ChronicND,
  title={Chronic nifedipine dosing enhances cephalexin bioavailability and intestinal absorption in conscious rats.},
  author={Francoise Berlioz and B Lep{\'e}re-Prevot and St{\'e}phanie D Julien and Annick Tsocas and Claude Carbon and Claude Roz{\'e} and Robert Farinotti},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2000},
  volume={28 11},
  pages={1267-9}
}
Cephalexin, a beta-lactam antibiotic, is rapidly absorbed via the di-and tripeptide intestinal transporters, as for many peptidomimetic drugs. Acute nifedipine has been shown to increase intestinal absorption of several beta-lactams: amoxicillin and cefixime in humans, and cephalexin in the rat. We showed previously that the nervous system was involved in the increasing effect of nifedipine on cephalexin intestinal absorption in anesthetized rats. The aim of the present study was 2-fold: 1) to… CONTINUE READING

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