Chronic nicotine treatment induces rat CYP2D in the brain but not in the liver: an investigation of induction and time course.

Abstract

OBJECTIVES CYP2D6 levels are higher in many brain regions of human smokers in comparison with nonsmokers. We have shown that CYP2D is expressed in rat brain regions and that enzyme activities correlate with protein and messenger ribonucleic acid (mRNA) levels. The aims of this study were to investigate whether nicotine can induce rat brain CYP2D, to… (More)

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