Chronic nicotine administration impairs activation of cyclic AMP-response element binding protein and survival of newborn cells in the dentate gyrus.

@article{Wei2012ChronicNA,
  title={Chronic nicotine administration impairs activation of cyclic AMP-response element binding protein and survival of newborn cells in the dentate gyrus.},
  author={Zelan Wei and Cherine Belal and Weihong Tu and Srinivasulu Chigurupati and Neema Jason Ameli and Youming Lu and Sic Lung Chan},
  journal={Stem cells and development},
  year={2012},
  volume={21 3},
  pages={411-22}
}
Chronic intake of nicotine can impair hippocampal plasticity, but the underlying mechanism is poorly understood. Here, we demonstrate that chronic nicotine administration in adult rats inactivates the cyclic AMP-response element binding protein (CREB), a transcription factor that regulates neurogenesis and other plasticity-related processes necessary for learning and memory. Consequently, we showed that impaired CREB signaling is associated with a significant decline in the production of new… CONTINUE READING

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