Chronic nickel-induced DNA damage and cell death: the protection role of ascorbic acid.

@article{Jia2008ChronicND,
  title={Chronic nickel-induced DNA damage and cell death: the protection role of ascorbic acid.},
  author={Jie Jia and Jie Chen},
  journal={Environmental toxicology},
  year={2008},
  volume={23 3},
  pages={401-6}
}
High consumption of nickel-containing products leads to more exposure of humans to nickel and its by-products. Except the lethal effect of acute nickel poison, chronic nickel exposure is also harmful to humans, but the mechanism of chronic nickel-induced cytotoxicity remains unclear. Here, we found that long-term exposure of Ni(2+) led to significant DNA fragmentation, cell death, and reactive oxygen species (ROS) generation in human leukemia HL-60 cells. Induction of Ni(2+) on DNA… CONTINUE READING