Chronic nephropathies of cocaine and heroin abuse: a critical review.

@article{Jaffe2006ChronicNO,
  title={Chronic nephropathies of cocaine and heroin abuse: a critical review.},
  author={Jared A Jaffe and Paul L. Kimmel},
  journal={Clinical journal of the American Society of Nephrology : CJASN},
  year={2006},
  volume={1 4},
  pages={655-67}
}
Renal disease in cocaine and heroin users is associated with the nephrotic syndrome, acute glomerulonephritis, amyloidosis, interstitial nephritis, and rhabdomyolysis. The pathophysiologic basis of cocaine-related renal injury involves renal hemodynamic changes, glomerular matrix synthesis and degradation, and oxidative stress and induction of renal atherogenesis. Heroin is the most commonly abused opiate in the United States. Previous studies identified a spectrum of renal diseases in heroin… CONTINUE READING