Chronic neonatal phencyclidine treatment produces age-related changes in pentylenetetrazol-induced seizures.

@article{Sircar1994ChronicNP,
  title={Chronic neonatal phencyclidine treatment produces age-related changes in pentylenetetrazol-induced seizures.},
  author={Ratna Sircar and Jana Vel{\'i}{\vs}kov{\'a} and Solomon L Mosh{\'e}},
  journal={Brain research. Developmental brain research},
  year={1994},
  volume={81 2},
  pages={185-91}
}
Although excitatory amino acids are known to play a critical role in the plasticity of developing brain, the behavioral effects of blocking the N-methyl-D-aspartate (NMDA) receptor-gated ion channel during development are not clear. Here we report the effects of chronic postnatal administration of 1-phenylcyclohexylpiperidine (phencyclidine or PCP), a NMDA channel blocker, on seizure susceptibility. To study the short-term effects of chronic PCP administration on pentylenetetrazol (PTZ)-induced… CONTINUE READING