Chronic neonatal isolation stress enhances cocaine-induced increases in ventral striatal dopamine levels in rat pups.

@article{Kosten2003ChronicNI,
  title={Chronic neonatal isolation stress enhances cocaine-induced increases in ventral striatal dopamine levels in rat pups.},
  author={Therese A. Kosten and Xiang Zhang and Priscilla Kehoe},
  journal={Brain research. Developmental brain research},
  year={2003},
  volume={141 1-2},
  pages={109-16}
}
Cocaine-induced increases in ventral striatal dopamine levels are enhanced in adult rats previously exposed to chronic stress. In neonatal rats, isolation from dam, nest, and siblings is stressful as evidenced by elevated corticosterone levels, an effect that increases with chronic isolation. Whether chronic neonatal isolation cross-sensitizes to cocaine leading to greater increases in ventral striatal dopamine levels was assessed in this study. Litters were assigned to isolate or non-handled… CONTINUE READING