A Retrospective Study of Clinical Profile and Long Term Outcome to Imatinib Mesylate Alone in Childhood Chronic Myeloid Leukemia in Chronic Phase.
CONTEXT Chronic Myeloid Leukemia (CML) constitutes around 3% of leukemia in the children and adolescent age group. AIMS The aim of the study was to evaluate the characteristics at presentation and the treatment outcome of CML in the children and adolescent age group. SETTINGS AND DESIGN Retrospective analysis was carried out at a single center in India. MATERIALS AND METHODS Thirteen patients (≤17 years) attending CML outdoor from April 2008 to August 2012 were included in the analysis. STATISTICAL ANALYSIS USED The mean and median of various parameters were calculated using a Microsoft excel sheet. SPSS 16.0 version software was used to calculate OS and PFS. RESULTS CML-CP was the most common phase at presentation. Maximum patients belonged to the 14 - 17 year old age group. Disease was common in the male sex. Splenic discomfort and asthenia were the most common symptoms and splenomegaly was the most common sign. CONCLUSIONS The treatment with Imatinib was effective and well-tolerated.