Chronic myeloid leukemia following heart transplantation and immunosuppression with tacrolimus.

@article{Sbenghe2011ChronicML,
  title={Chronic myeloid leukemia following heart transplantation and immunosuppression with tacrolimus.},
  author={Maria M Sbenghe and Alin Dulau Florea and Paul Mather and Elena Gitelson},
  journal={Clinical advances in hematology & oncology : H&O},
  year={2011},
  volume={9 8},
  pages={623-7}
}
Chronic myeloid leukemia (CML) rarely develops following organ transplantation. Chronic immunosuppressive therapy is believed to be responsible for secondary malignancies, mainly the tumors of the lymphoid tissue and skin neoplasms.1-3 The known mechanisms involved in the development of secondary malignancies include decreased immunosurveillance due to chronic immunosuppression and direct tumorigenic effect of the immunosuppressive medications. Little is known yet of the factors that may… CONTINUE READING