Chronic myeloid leukemia--advances in biology and new approaches to treatment.

  title={Chronic myeloid leukemia--advances in biology and new approaches to treatment.},
  author={John M. Goldman and Junia V. Melo},
  journal={The New England journal of medicine},
  volume={349 15},
N Engl J Med 2003;349:1451-64. Copyright © 2003 Massachusetts Medical Society. hronic myeloid leukemia (cml) was probably the first form of leukemia to be recognized as a distinct entity. In 1845, two patients were described as having massive splenomegaly associated with leukocytosis, 1 which seemed to be a novel entity not explained by the other causes of splenomegaly, such as tuberculosis, that were already widely accepted in the 1840s. The first important clue to its pathogenesis came only… CONTINUE READING
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