Chronic myeloid leukemia: a historical perspective.


Patients with splenomegaly and abnormally high leukocyte counts were first recognized in France, Germany, and Scotland in the 1840s. The only well-documented therapy in the 19th century was use of arsenic in one or other form, which did undoubtedly reduce the leukocyte count but probably did little or nothing to prolong life. These early cases were probably… (More)
DOI: 10.1053/j.seminhematol.2010.07.001


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