Chronic myelocytic leukemia. Origin of some lymphocytes from leukemic stem cells.

@article{Fialkow1978ChronicML,
  title={Chronic myelocytic leukemia. Origin of some lymphocytes from leukemic stem cells.},
  author={Philip J. Fialkow and A Michael Denman and Robert J. Jacobson and Mark N Lowenthal},
  journal={The Journal of clinical investigation},
  year={1978},
  volume={62 4},
  pages={815-23}
}
In three patients with chronic myelocytic leukemia who were heterozygous at the X-linked glucose-6-phospháte dehydrogenase locus, lymphocytes were studied to determine if they had the same stem cell origin as the leukemic myeloid cells. Normal tissues such as skin had both B and A glucose-6-phosphate dehydrogenase isoenzymes, but the leukemic myelogenous cells displayed only one isoenzyme type, consistent with their clonal origin. A population of cells with undoubted thymus-derived (T… CONTINUE READING