Chronic musculoskeletal pain in patients with the chronic fatigue syndrome: A systematic review

  title={Chronic musculoskeletal pain in patients with the chronic fatigue syndrome: A systematic review},
  author={Mira Meeus and Jo Nijs and Kenny de Meirleir},
  journal={European Journal of Pain},

Association Between Fatigue and Pain in Rheumatoid Arthritis: Does Pain Precede Fatigue or Does Fatigue Precede Pain?

This study investigated the longitudinal relationship between fatigue and pain in patients with RA using time‐lag models to establish a temporal association between symptoms of rheumatoid arthritis and fatigue.

Is Chronic Fatigue Syndrome in Older Patients a different disease? – a clinical cohort study

A clinical cohort study is performed to examine and differentiate the clinical and autonomic features in CFS patients aged over 50.

Chronic Musculoskeletal Pain: Prevalence, impact and multidisciplinary treatment in Iceland

Felag sjukraþjalfara Fraeðslunet Suðurlands Heilsustofnun NLFI Namsbraut i sjukraþjalfun, Haskola Islands

ASICs Mediate Pain and Inflammation in Musculoskeletal Diseases.

This review discusses the properties of different types of ASICs, factors affecting their pH sensitivity, and their role in musculoskeletal hyperalgesia and inflammation.

Current evidence for a modulation of low back pain by human genetic variants

Polymorphisms causing complex syndromes with a loss of pain perception and modulating the metabolism of analgesics are studied.

MicroRNAs as Biomarkers of Pain Intensity in Patients With Chronic Fatigue Syndrome

This study evaluated a set of miRNAs as diagnostic biomarkers of pain intensity in adolescents with chronic fatigue syndrome and correlated the expression of thesemiRNAs with the levels of inflammatory markers and pain‐related comorbidities in adolescence with CFS and healthy controls.

Recovery of upper limb muscle function in chronic fatigue syndrome with and without fibromyalgia

Recovery of upper limb muscle function from a fatiguing exercise in CFS patients with (CFS+FM) and without (C FS‐only) comorbid fibromyalgia are examined and their results are compared with a matched inactive control group.

Central sensitization: a biopsychosocial explanation for chronic widespread pain in patients with fibromyalgia and chronic fatigue syndrome

The hypothesis that central sensitization is also responsible for the sustaining pain complaints in CFS is proposed, based on the hyperalgesia and allodynia reported in C FS, on the elevated concentrations of nitric oxide presented in the blood of CFS patients, in addition to the typical personality styles seen in Cfs and on the brain abnormalities shown on brain images.

Pain in patients with chronic fatigue syndrome: time for specific pain treatment?

It is concluded that musculoskeletal factors are unlikely to account for pain from CFS, and it is advocated to optimize current CFS treatment protocols by targeting the underlying mechanism for those patients having severe pain.

Fibromyalgia and Fatigue: Central Processing, Widespread Dysfunction

  • P. FinanA. Zautra
  • Psychology, Medicine
    PM & R : the journal of injury, function, and rehabilitation
  • 2010



The Localization of Pain in Chronic Fatigue Syndrome on a Pain Drawing According to Grid Areas

Most frequent experiences of pain were in the neck and right buttock, upper parts of the chest, left calf, and lower back, according to 23 women with chronic symptoms of fatigue and pain.

Exercise lowers pain threshold in chronic fatigue syndrome

Pain complaints in patients with fibromyalgia versus chronic fatigue syndrome

The abnormalities in the neuroendocrine axes that are common to FM and CFS as well as the abnormalities in central neuropeptide levels and functional brain activity that differentiate these disorders are identified.

Primary fibromyalgia and the chronic fatigue syndrome

Symptoms of painful glands or fever might serve as clinical indicators, distinguishing between fibromyalgia and the chronic fatigue syndrome.

The socioeconomic impact of chronic pain.

A concern with the socioeconomic effects of chronic nonmalignant pain, as well as the human aspects, inspired a search of the literature for evidence, and three main areas of interest were identified, socioeconomic statistics; pain prevalence in the community, and the quality of life issues.

High frequency of fibromyalgia in patients with chronic fatigue seen in a primary care practice.

The majority of patients with debilitating chronic fatigue, including those who met criteria for CFS, met the historical and tender point diagnostic criteria for fibromyalgia, and the presence of current musculoskeletal pain will identify those CFS patients who have Fibromyalgia.

A four-year follow-up study in fibromyalgia. Relationship to chronic fatigue syndrome.

To what extent fibromyalgia patients later on developed presumpted causative somatic diseases and to examine symptoms and muscle strength some years after the diagnosis of fibromy arthritis was established were examined.

The Chronic Fatigue Syndrome: A Comprehensive Approach to Its Definition and Study

We have developed a conceptual framework and a set of research guidelines for use in studies of the chronic fatigue syndrome. The guidelines cover the clinical and laboratory evaluation of persons