Chronic multifocal non-bacterial osteomyelitis in hypophosphatasia mimicking malignancy

Abstract

BACKGROUND Hypophosphatasia (HP) is characterized by a genetic defect in the tissue-nonspecific alkaline phosphatase (TNSALP) gene and predominantly an autosomal recessive trait. HP patients suffer from reduced bone mineralization. Biochemically, elevated concentrations of substrates of TNSALP, including pyridoxal-5'-phosphate and inorganic pyrophosphate… (More)

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@article{Girschick2007ChronicMN, title={Chronic multifocal non-bacterial osteomyelitis in hypophosphatasia mimicking malignancy}, author={Hermann Josef Girschick and Etienne Mornet and Meinrad Joachim Beer and Monika Warmuth-Metz and Peter R. Schneider}, journal={BMC Pediatrics}, year={2007}, volume={7}, pages={3 - 3} }