Chronic morphine induces up‐regulation of the pro‐apoptotic Fas receptor and down‐regulation of the anti‐apoptotic Bcl‐2 oncoprotein in rat brain

@article{Boronat2001ChronicMI,
  title={Chronic morphine induces up‐regulation of the pro‐apoptotic Fas receptor and down‐regulation of the anti‐apoptotic Bcl‐2 oncoprotein in rat brain},
  author={M A Boronat and M. Julia Garc{\'i}a-Fuster and Jes{\'u}s A Garc{\'i}a-Sevilla},
  journal={British Journal of Pharmacology},
  year={2001},
  volume={134}
}
This study was designed to assess the influence of activation and blockade of the endogenous opioid system in the brain on two key proteins involved in the regulation of programmed cell death: the pro‐apoptotic Fas receptor and the anti‐apoptotic Bcl‐2 oncoprotein. The acute treatment of rats with the μ‐opioid receptor agonist morphine (3 – 30 mg kg−1, i.p., 2 h) did not modify the immunodensity of Fas or Bcl‐2 proteins in the cerebral cortex. Similarly, the acute treatment with low and high… Expand
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