Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system

@inproceedings{Schlosburg2010ChronicML,
  title={Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system},
  author={Joel E. Schlosburg and Jacqueline L. Blankman and Jonathan Z. Long and Daniel K Nomura and Bin Pan and Steven G Kinsey and P. T. Nguyen and Divya Ramesh and Lamont Booker and J. J. Burston and Elizabeth Anne Thomas and D. E. Selley and L. J. Sim-Selley and Qingsong Liu and Aron H. Lichtman and Benjamin F Cravatt},
  booktitle={Nature Neuroscience},
  year={2010}
}
Prolonged exposure to drugs of abuse, such as cannabinoids and opioids, leads to pharmacological tolerance and receptor desensitization in the nervous system. We found that a similar form of functional antagonism was produced by sustained inactivation of monoacylglycerol lipase (MAGL), the principal degradative enzyme for the endocannabinoid 2-arachidonoylglycerol. After repeated administration, the MAGL inhibitor JZL184 lost its analgesic activity and produced cross-tolerance to cannabinoid… CONTINUE READING
Highly Influential
This paper has highly influenced 30 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 184 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 55 references

Similar Papers

Loading similar papers…